UNRAVELLING ANTIGENIC CROSS-REACTIONS TOWARD THE WORLD OF CORONAVIRUSES: EXTENT OF THE STABILITY OF SHARED EPITOPES AND SARS-COV-2 ANTI-SPIKE CROSS-NEUTRALIZING ANTIBODIES

The human immune repertoire retains the molecular memory of a very great diversity of target antigens (epitopes) and can recall this upon a second encounter with epitopes against which it has previously been primed.Although genetically diverse, proteins of coronaviruses exhibit sufficient conservation to lead to antigenic cross-reactions.In this re

BackgroundThe global burden of 9021 glow chronic respiratory diseases (CRDs) disproportionally affects Roma populations.Health interventions addressing CRD among Roma or other vulnerable groups often fail to be effective, as their implementation strategy misaligns with the local context.To design context-driven strategies, we studied CRD-related be

In experimental acute exudative inflammation, caused by Difco agar injection in mice hind leg, lipids derived from maral antlers and peat decreased the leg inflammatory edema mudra fitted tee and prolonged the pain reaction latent period; in analogous model in rats prevented the edema progression.In model of proliferative inflammation lipids reduce

Introduction/purpose: The paper presents a numerical simulation of an impact of a 12.7 mm projectile on an armored metal plate with a velocity of 500 m/s at a distance of 900 m.Numerical simulations offer the possibility of drastically reducing the time required to obtain results in comparison to the time required for planning, organization and exe

AIM: Accumulating evidence suggests that extracellular galectin-1 and galectin-3 promote angiogenesis.Increased expression of galectin-1 and/or galectin-3 has been reported to be associated with tumour progression.Thus, it is critical to identify their influence on angiogenesis.METHODS: We examined the individual and combined effects of galectin-1